Pregnancy Complicated by Maternal MODY 3 and Paternal MODY 2 Diabetes and Subsequent Rapidly Falling Insulin Requirement
نویسندگان
چکیده
منابع مشابه
GCK-MODY (MODY 2) Caused by a Novel p.Phe330Ser Mutation
Maturity onset diabetes of the young (MODY) is a monogenic form of diabetes inherited as an autosomal dominant trait. The second most common cause is GCK-MODY due to heterozygous mutations in the GCK gene which impair the glucokinase function through different mechanisms such as enzymatic activity, protein stability, and increased interaction with its receptor. The enzyme normally acts as a glu...
متن کاملMeglitinide analogues in adolescent patients with HNF1A-MODY (MODY 3).
For pediatric patients with hepatocyte nuclear factor-1A (HNF1A)-maturity-onset diabetes of the young (MODY 3), treatment with sulfonylureas is recommended. In adults with HNF1A-MODY, meglitinide analogues achieve lower postprandial glucose levels and pose a lower risk of delayed hypoglycemia compared with sulfonylureas. This therapy has not yet been reviewed in pediatric patients. We report on...
متن کاملMody
EARLY HISTORY—In the academic year 1949–1950, one of us (S.S.F.), while a first-year Fellow in Endocrinology and Metabolism at the University of Michigan (Jerome W. Conn, Division Chief), initiated a prospective, long-term study on the diagnosis, natural history, and clinical genetics of diabetes. Starting with known diabetic patients from the Diabetes Clinic, I recruited their apparently healt...
متن کاملMODY 2 Diabetes: An Unusual Presentation of Diabetes
Diabetes mellitus includes a heterogeneous mix of metabolic diseases characterized by chronic hyperglycemia. Some forms of this illness respond to specific etiological or pathogenic characteristics, but the underlying etiology is unknown. The most common varieties of diabetes mellitus are Type 1 and Type 2, but there are other types. Numerous common polymorphisms (approximately 50 to date) weak...
متن کاملFirst UK survey of paediatric type 2 diabetes and MODY.
AIMS To estimate the UK prevalence of childhood type 2 diabetes and maturity onset diabetes of the young (MODY), and distinguish them from each other and from type 1 diabetes. METHODS The British Society for Paediatric Endocrinology and Diabetes Clinical Trials/Audit Group undertook a cross-sectional questionnaire survey of all paediatric diabetes centres during 2000, collecting data on all c...
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ژورنال
عنوان ژورنال: Case Reports in Obstetrics and Gynecology
سال: 2018
ISSN: 2090-6684,2090-6692
DOI: 10.1155/2018/9451061